abstract：:BACKGROUND Establishing a shunt-induced pulmonary arterial hypertension (PAH) model in mice would be of great scientific value, but no such models have been reported to date. Here, we established a shunt-associated PAH in mice to investigate the characteristics of pulmonary vascular remodeling, which provides a new pl...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang M,Feng Z,Huang R,Sun C,Xu Z

更新日期：2018-03-19 00:00:00

abstract：:BACKGROUND miR-23b overexpression can promote cardiomyocyte apoptosis and reduce cell growth under hypoxic conditions, suggesting that miR-23b acts as a biomarker for ST-elevation myocardial infarction (STEMI). The aim of this study was to investigate the effect of miR-23b on STEMI patients. MATERIAL AND METHODS We en...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang J,Li Y,Zhao Q

更新日期：2018-03-14 00:00:00

abstract：:BACKGROUND Beta-secretase 1 (BACE1) is a rate-limiting enzyme in the generation of amyloid beta peptides, which are associated with Alzheimer's disease (AD). It has been reported that Schisandrin B could improve cognitive functions in animal models of AD, but the underlying mechanisms are not completely understood. MA...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li Z,Liu XC,Li R,Chang J

更新日期：2018-02-28 00:00:00

abstract：:BACKGROUND Endothelial progenitor cells (EPCs) were found to be a potential therapeutic choice for low extremity deep vein thrombosis. The aim of our research was to investigate the effect of resveratrol (RSV) on EPCs that may promote thrombus resolution and its potential pathway. MATERIAL AND METHODS EPCs were pretre...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang Y,Du X,Li W,Sang H,Qian A,Sun L,Li X,Li C

更新日期：2018-02-15 00:00:00

abstract：:BACKGROUND The aim of this study was to identify the predictors of deterioration in sagittal balance in patients with adult scoliosis following long fusion arthrodesis to L5. MATERIAL AND METHODS A retrospective clinical study included 63 patients with adult scoliosis who underwent long fusion arthrodesis to L5, betwe...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Gao X,Wang L,Yan C,Gao Y,Shen Y

更新日期：2018-02-14 00:00:00

abstract：:BACKGROUND Insulin resistance (IR) and inflammation are associated with increased risk of complications in chronic kidney disease (CKD) patients. However, the relationship between IR and the important proinflammatory interleukin-1β (IL-1β) is unclear in CKD patients. MATERIAL AND METHODS We conducted a cross-sectional...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Bi X,Ai H,Wu Q,Fan Q,Ding F,Hu C,Ding W

更新日期：2018-02-13 00:00:00

abstract：:BACKGROUND Angiopoietin-like 4 (ANGPTL4) is neuroprotective when administered acutely for the treatment of cerebral ischemia. The aim of the present study was to evaluate the preventive effects of ANGPTL4 on the formation of brain edema and to determine whether it promotes the recovery of neurological function followi...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Qiu Z,Yang J,Deng G,Fang Y,Li D,Zhang S

更新日期：2018-02-12 00:00:00

abstract：:BACKGROUND Calcium phosphate cement (CPC) has been applied as a biodegradable antibiotic carrier in osteomyelitis. However, the drug delivery, antibacterial efficacy, and degradation rate of CPC are insufficient and require further improvement in clinical application. MATERIAL AND METHODS Vancomycin-loaded CPC columns...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Shi M,Chen L,Wang Y,Wang W,Yan S

更新日期：2018-02-08 00:00:00

abstract：:BACKGROUND This study analyzed the macular 3D-OCT images of Vogt-Koyanagi-Harada disease (VKH) in uveitis, explored the characteristics of 3D-OCT images of the macular region of VKH, and assessed which characteristics contribute most to VKH diagnosis. MATERIAL AND METHODS The 3D-OCT examination of 25 cases of VKH was ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhao GL,Li RZ,Pang YH,Wang XQ,Peng HJ,Wei JF,Zhou Z

更新日期：2018-02-03 00:00:00

abstract：:BACKGROUND The objective of this study was to evaluate clinical and radiographic outcomes of volar plate versus intramedullary nailing for fixation of distal radius fractures. MATERIAL AND METHODS This retrospective study included 64 patients with extra-articular and simple intra-articular fractures of the distal radi...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Çalbıyık M,Ipek D

更新日期：2018-01-30 00:00:00

abstract：:BACKGROUND The aim of this study was to investigate the expression of long non-coding RNAs (lncRNA) cancer susceptibility candidate 2a (CASC2a) in patients with urothelial carcinoma of the bladder (UCB) and its predictive value in the recurrence of UCB after radical cystectomy (RC). MATERIAL AND METHODS Tumor and pair...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li Z,Wang KE,Zhou XL,Zhou J,Ye CH

更新日期：2018-01-23 00:00:00

abstract：:BACKGROUND The aim of this study was to investigate the expression level of martrilin-3 (MATN3) in patients with gastric adenocarcinoma (GAC) and to investigate the prognostic significance of MATN3. MATERIAL AND METHODS Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) data were used to predict the expr...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wu PL,He YF,Yao HH,Hu B

更新日期：2018-01-18 00:00:00

abstract：:BACKGROUND It has been reported that overt and mild thyroid dysfunctions are associated with insulin resistance (IR). We performed this retrospective study to evaluate the relationships between thyroid-stimulating hormone (TSH) levels within the reference range and IR. MATERIAL AND METHODS A total of 447 outpatients w...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhu P,Liu X,Mao X

更新日期：2018-01-17 00:00:00

abstract：:BACKGROUND Robot-assisted radical prostatectomy (RARP) is increasingly used worldwide, but comparisons of perioperative, functional, and oncologic outcomes among RARP, laparoscopic radical prostatectomy (LRP), and open radical prostatectomy (ORP) remain inconsistent. MATERIAL AND METHODS Systematic literature searches...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Du Y,Long Q,Guan B,Mu L,Tian J,Jiang Y,Bai X,Wu D

更新日期：2018-01-14 00:00:00

abstract：:BACKGROUND Age-related macular degeneration (AMD) is the leading cause of blindness in people aged 65 years and older in developed countries. The pathogenesis of AMD has been linked to mechanisms involving inflammation, oxidative stress, and basal laminar deposit formation between retinal pigment epithelium (RPE) cell...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Banevicius M,Vilkeviciute A,Kriauciuniene L,Liutkeviciene R,Deltuva VP

更新日期：2018-01-10 00:00:00

abstract：:BACKGROUND Post-traumatic syringomyelia (PTS) is a common disease after spinal cord injury (SCI). The present study was performed to evaluate the advantages of diffusion tensor imaging (DTI) in estimating SCI and prognosing PTS in SCI rats. MATERIAL AND METHODS Forty rats were divided into 3 groups based on the extent...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang C,Chen K,Han X,Fu J,Douglas P,Morozova AY,Abakumov MA,Gubsky IL,Li D,Guo J,Zhang X,Wang G,Chekhonin VP

更新日期：2018-01-09 00:00:00

abstract：:BACKGROUND Gremlin has been reported to be up-regulated in glomerular mesangial cells in diabetic nephropathy (DN). However, the regulation of gremlin in podocytes is still rarely reported. This study aimed to investigate the underlying mechanisms by which gremlin mediates the pathogenesis of DN via transforming growt...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wang XB,Zhu H,Song W,Su JH

更新日期：2018-01-09 00:00:00

abstract：:Long non-coding RNA (lncRNA) is a kind of non-coding RNA with transcripts more than 200 bp in length. LncRNA can interact with the miRNA as a competing endogenous RNA (ceRNA) to regulate the expression of target genes, which play a significant role in the initiation and progression of tumors. In this study, we explore...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li F,Huang C,Li Q,Wu X

更新日期：2018-01-03 00:00:00

abstract：:BACKGROUND The objective of this study was to analyze the factors that can increase the possibility of mandibular canal (MC) defect in Chinese people, to evaluate the risk of nerve impairment, and to choose the proper operative method to reduce the risk of mandibular alveolar nerve injury during the extraction of mand...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Chen Y,Liu J,Pei J,Liu Y,Pan J

更新日期：2018-01-02 00:00:00

abstract：:BACKGROUND Fucoxanthin is a carotenoid present in the chloroplasts of brown seaweeds. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine that selectively induces apoptosis in many tumor cells and is an attractive candidate for antitumor therapies. MATERIAL AND METHODS After human cervical ca...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Jin Y,Qiu S,Shao N,Zheng J

更新日期：2018-01-01 00:00:00

abstract：:BACKGROUND Patient-specific instruments have recently gained attention for ensuring the accuracy of osteotomy and correct alignment in total knee arthroplasty (TKA). We aimed to report our experience with TKA performed by using CT-based 3D model of cutting guides in our clinic. MATERIAL AND METHODS A total of 36 patie...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Çalbıyık M

更新日期：2017-12-29 00:00:00

abstract：:A number of electrophysiological tests have been proposed for the initial diagnostic assessment or for the follow-up phase of patients affected by Ménière disease. The most common are: (i) vestibular evoked myogenic potentials (VEMPs); (ii) electrocochleography (ECochG); and (iii) otoacoustic emissions (OAEs). This pa...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Ciorba A,Skarżyński PH,Corazzi V,Bianchini C,Aimoni C,Hatzopoulos S

更新日期：2017-12-28 00:00:00

abstract：:BACKGROUND Berberine, a herbal extract, has been reported to protect against inflammatory disorders. The adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway can be activated by berberine and inhibited by the synthetic, reversible AMP-competitive inhibitor, Compound C. The aim of this stu...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wang Y,Zhou L,Li Y,Guo L,Zhou Z,Xie H,Hou Y,Wang B

更新日期：2017-12-28 00:00:00

abstract：:BACKGROUND Balloon kyphoplasty (KP) has been widely applied in the treatment of elderly patients with osteoporosis vertebral compression fracture (OVCF), but there has been little research on the pain relief effect. Therefore, we performed this study of patients who received KP. The study included a set of fluoroscopy...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Mei X,Sun ZY,Zhou F,Luo ZP,Yang HL

更新日期：2017-12-18 00:00:00

abstract：:BACKGROUND The aim of this study was to evaluate the effect of oral contraceptive pills (OCP) on the macula, the retinal nerve fiber layer (RNFL), and choroidal thickness (CT). MATERIAL AND METHODS A total of 24 healthy women taking monophasic OCP (3 mg drospirenone and 0.03 mg ethinylestradiol) for contraception only...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Madendag Y,Acmaz G,Atas M,Sahin E,Tayyar AT,Madendag IÇ,Özdemir F,Senol V

更新日期：2017-11-27 00:00:00

abstract：:BACKGROUND The purpose of the study was to investigate the ability of microbubbles (MBs) targeting interleukin-18 (IL-18) to detect plaques in a rabbit atherosclerotic plaque model. MATERIAL AND METHODS A rabbit atherosclerotic plaque model was established. The locations of the atherosclerotic plaques were verified by...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Jiang ZZ,Liu XT,Ma CY,He C,Li XY,Hou CL,Cheng ZS,Xia GY

更新日期：2017-11-16 00:00:00

abstract：:BACKGROUND Preeclampsia is a serious multisystem disorder of human gestation, affecting up to 10% of pregnant women worldwide, and results in maternal morbidity and mortality. The aim of this study was to determine the gene expression pattern and methylation status of the promoter of the WNT2 gene in placentas from pa...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu Y,Ma Y

更新日期：2017-11-07 00:00:00

abstract：:BACKGROUND This study aimed to determine and validate that use of a nomogram could enhance the predictability of small-incision lenticule extraction (SMILE) surgery. MATERIAL AND METHODS 195 eyes from 98 patients were enrolled in group 1, and 46 eyes from 26 patients in group 2. Uncorrected and corrected distance visu...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liang G,Chen X,Zha X,Zhang F

更新日期：2017-10-30 00:00:00

abstract：:BACKGROUND Predicting the occurrence of severe postreperfusion syndrome (PRS) is clinically challenging. We investigated whether the flushed fluid potassium concentration (FFK) was associated with severe PRS in deceased donor liver transplantation (DDLT). MATERIAL AND METHODS Forty adult DDLT recipients were enrolled ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang L,Tian M,Sun L,Zhu Z

更新日期：2017-10-29 00:00:00

abstract：:BACKGROUND The fast pace of life, promoting fast food consumption and low physical activity, has resulted in obesity and/or diabetes as being serious social problems. The aim of the present study was to evaluate concentrations of selected adipokines (leptin, adiponectin, resistin, and visfatin) and to assess the lepti...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Kocot J,Dziemidok P,Kiełczykowska M,Hordyjewska A,Szcześniak G,Musik I

更新日期：2017-10-19 00:00:00

abstract：:BACKGROUND Emotional state can be affected by different training loads. The aim of this study was to explore the changes of rat emotional state, as well as the mRNA and protein expressions of N-methyl-D-aspartate receptors (NMDARs), postsynaptic density 95 (PSD-95), and kinesin family member 17 (KIF-17) in the hippoca...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Ren H,Yu X,Yu L,Zhang Y,Xie H,Shi N,Chen L

更新日期：2017-10-17 00:00:00

abstract：:BACKGROUND To explore the effect of hypoxic preconditioning on the JAK/STAT3 signaling pathway and its effect on trophoblast cell viability and angiogenesis in preeclampsia (PE). MATERIAL AND METHODS Placental tissues from normal pregnant women and PE patients were collected to detect the expression levels of JAK and ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xu C,Li X,Guo P,Wang J

更新日期：2017-10-14 00:00:00

abstract：:BACKGROUND Not all patients with spinal cord compression due to cervical spondylotic myelopathy (CSM) have clinical symptoms and signs. The aim of this study was to investigate and compare the imaging findings in asymptomatic and symptomatic patients with CSM with mild to moderate cervical spinal cord compression. MAT...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Cao JM,Zhang JT,Yang DL,Yang YP,Xia HH,Yang L

更新日期：2017-10-13 00:00:00

abstract：:BACKGROUND Increasing evidence suggests that delayed diagnosis in Crohn's disease is associated with a complicated disease course. The aim of this study was to explore the association between delayed diagnosis and the timing of the first Crohn's disease-related intestinal surgery. MATERIAL AND METHODS A retrospective ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Hong Z,Ren J,Li Y,Wang G,Gu G,Wu X,Ren H,Li J

更新日期：2017-10-09 00:00:00

abstract：:BACKGROUND The pathogenesis of schizophrenia is complex and oligodendrocyte abnormality is an important component of the pathogenesis found in schizophrenia. This study was designed to evaluate the function of olig2 in cuprizone-induced schizophrenia-like symptoms in a mouse model, and to assess the related mechanisms...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu H,Zhai J,Wang B,Fang M

更新日期：2017-10-09 00:00:00

abstract：:BACKGROUND Surface characters of culture plates affect cellular behaviors such as cellular alignment and elongation. Microgrooves guide the cell growth along the grooves and spread. The aim of this study was to observe the effect of fibronectin (FN)-coated micro-grooved titanium plates on the alignment, spread, adhesi...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Jian X,Huang W,Wu D,You D,Lin Z,Chen J

更新日期：2017-10-04 00:00:00

abstract：:BACKGROUND Breast cancer is among the deadliest cancers across the world and is responsible for countless deaths. There is an urgent need for co-delivery systems which can simultaneously transport both drug and gene into a single cancer cell with low toxicity and high anti-angiogenesis efficiency. MATERIAL AND METHODS...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhao L,Zhao W,Liu Y,Chen X,Wang Y

更新日期：2017-10-02 00:00:00

abstract：:BACKGROUND Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) aggravates the overall severity in COPD patients, resulting in severe morbidity and mortality. However, there are no objective biomarkers currently available to predict the development of AECOPD. Several studies have indicated that galecti...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Feng W,Wu X,Li S,Zhai C,Wang J,Shi W,Li M

更新日期：2017-09-26 00:00:00

abstract：:BACKGROUND Acute cerebral infarction is a major clinical subtype of ischemic stroke that has become a leading cause of death and disability worldwide. Aldehyde dehydrogenase 2 (ALDH2) is an important oxidative enzyme in alcohol metabolism. The polymorphism of ALDH2 Glu504Lys polymorphism modifies the activity of this ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Qu Y,Zhang H,Li H,Yu L,Sun Y,Chen Y

更新日期：2017-09-23 00:00:00

abstract：:BACKGROUND This study aimed to identify more potential genes and miRNAs associated with the pathogenesis of intracranial aneurysms (IAs). MATERIAL AND METHODS The dataset of GSE36791 (accession number) was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened for in ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Bo L,Wei B,Wang Z,Kong D,Gao Z,Miao Z

更新日期：2017-09-20 00:00:00